CHM 406 - NMR Spectroscopy

0.5 course unit

Students will study modern techniques of nuclear magnetic resonance (NMR) spectroscopy and apply them to problems in structure determination and analysis of organic compounds and biomolecules. Operation of a modern high field multinuclear NMR spectrometer will be featured with an emphasis on what information different NMR experiments can provide and how to interpret the results. Sufficient theoretical background will be included to allow students to optimize instrument parameters for specific experiments. Topics will include a thorough coverage of one-dimensional 1H NMR spectroscopy, various types of 13C NMR (DEPT, APT, etc.), other NMR-active nuclei such as 31P, and various homonuclear and heteronuclear two-dimensional NMR experiments (COSY, HSQC, HMBC, etc.). Two class hours per week.
Prerequisite(s): CHM 202 Organic Chemistry II or CHM 204, 206 Organic Chemistry IIA or permission of instructor.